Personalized genetics - Zan Mitrev Clinic

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Personalized genetics

ANALYSIS WITH MASSIVE PARALLEL SEQUENCING (NEXT GENERATION SEQUENCING – NGS)

Each person’s genetic makeup is slightly different from everyone else’s, often in very important ways that affect one’s health. By sequencing entire genomes and exomes, we can peer deep into the molecular identity of the patient and read the information that is written in the genes. Next generation sequencing (NGS)on genomes and exomes proved to be a revolutionary technology that allowed us to address many biological issues, and demonstrated the capacity for incredibly fast sequencing of DNA, opening the doors for previously unimaginable scientific and clinical achievements and new biological applications. The effect of these technologies on the discovery of new genomic variations is definitely one of the greatest achievements in medicine, and perhaps in general.

Depending on specific needs of each patient, different approaches are used.

Proactive determination of risks for all diseases in healthy people

  1. Whole genome sequencing (WGS) (х30) – all genes and intergenic regions
  2. Whole exome sequencing (WES) (х100) – all protein-coding genes
  3. Clinical exome sequencing (CES) – ~5000 clinically relevant genes

Proactive determination of risks for cancer in healthy people

  1. Whole genome sequencing (WGS) (х30) – all genes and intergenic regions
  2. Whole exome sequencing (WES) (х100) – all protein-coding genes
  3. Clinical exome sequencing (CES) – ~5000 clinically relevant genes
  4. Gene panels

Proactive determination of the carrier status for rare diseases

  1. Whole genome sequencing (WGS) (х30) – all genes and intergenic regions
  2. Whole exome sequencing (WES) (х100) – all protein-coding genes
  3. Clinical exome sequencing (CES) – ~5000 clinically relevant genes