Zan Mitrev's Team

Aco Kostovski MD, PhD

Pediatrics specialist
Pediatric gastroenterohepatology subspecialist

aco.kostovski@zmc.mk

2000

Sub-specialization in pediatric gastroenterohepatology, Medical Faculty, Skopje, Macedonia

1994

Master of Medical Sciences – Master Thesis “Gastroesophageal Reflux during Childhood – Clinical, Diagnostic, and Evolutive Characteristics” 1998: Doctoral Thesis – “Assessment of the Gastroesophageal Reflux and Associated Complications during Childhood – Significance of  the Computerized 24-hour pH Metrics of the Dietary Esophagus”

1992

Clinical and professional study – Polish and American Pediatrics Institute, Krakow and Warsaw Memorial Hospital, Poland

1991

Clinical study for Pediatric gastroenterohepatology, University Clinical Center Tampere, Finland

1983-1987

Pediatrics specialization, University Clinic for Children’s Diseases, Skopje, Macedonia

1980

Medical Faculty, University Ss. Cyril and Methodious, Skopje, Macedonia, as the top performing student of my class.

Academic titles

  • Full professor of the Medical Faculty, University Ss. Cyril and Methodius, Skopje, Macedonia
    • Visiting professor at the Medical Faculty, Josip Juraj Strossmayer in Osjek, Croatia

2024 – present

Pediatrics specialist in the Zan Mitrev Clinic, Skopje

1980-2024

University Clinic for Children’s Diseases.

2019

Head of the hepatology department, University Clinic for Children’s Diseases

2007-2012

Medical director of  the PuHCI University Clinic for Children’s Diseases for two terms

2001

Head of department for disturbed motility of the digestive system with digestive endoscopy (with a cabinet for computerized 24-hour pH metrics of the dietary esophagus)

2000-2002

Medical director of  the PuHCI University Clinic for Children’s Diseases for two terms

1993

Head of the malabsorptive syndromes unit

1987

Pediatrics specialist, Gastroenterohepatology department, University Clinic for Children’s Diseases

  • Clinical and research stays in European and other international centers for various diagnostic methods in pediatric gastroenterology (Tampere, Munich, Goteborg, Houston, Paris, Boston, London, Barcelona, Brussels, Amsterdam)
  • Invited to give lectures in numerous congresses, symposia, workshops, seminars in the area of pediatric gastroenterology and hepatology organized in the country and abroad (Ljubljana, Split, Belgrade, Maribor, Podgorica, Budva, Zlatibor, etc.)
  • Graduate course in health management, Budapest, Hungary
  • Participation in the ESPGHAN (European society for pediatric gastroenterohepatology and nutrition) annual meetings every year since 1994.
  • Organization and lectures in the ESPGHAN Summer School in Ohrid in 2009 (ESPGHAN South-Eastern Summer School for Pediatric Gastroenterohepatology)
  • Active participation on the annual meetings of SSIEM (Society for study of inborn errors of metabolism), Vienna, Geneva, Birmingham, Barcelona, Innsbruck, Lyon, and introduction of protocols form diagnostics and treatment of metabolic hepatic diseases
  • Short clinical stay in the University Clinic for Children’s Diseases in Heidelberg in 2011 in the department for congenital metabolic diseases and neonatal screening, diagnosis of Wilson’s disease, hepatic transplantation
  • As a pediatric gastroenterohepatology specialist, diagnostic and management of patients with metabolic hepatic diseases and introducing, for the first time in Macedonia, orphan medicine therapy (Nitisinone, Cerezyme, Miglustat, Maralixibat)
  • Professional cooperation with the University Clinic in Heidelberg, Germany in the area of diagnosing rare diseases, Bicêtre – Paris, Bergamo – Italy, AKH Vienna, Charles University in Prague
  • Accreditation of a third cycle curriculum – doctoral studies at the Medical Faculty in 2011, qualified mentor since first enrolment.
  • Chief researcher on a project financed by the Ministry of Education and Science of Macedonia, entitled “Analysis of the Findings from the Computrized 24-hours pH Metrics of the Dietary Esophagus in the Assessment of the Gastroesophageal Reflux in Children with Respiratory Disease and Treatment Evaluation”
  • Chief researcher and co-researcher in several internation projects implemented by ESPGHAN for GERD, Coeliac disease, eosinophile esophagitis, functional gastrointestinal diseases, metabolic hepatic diseases
  • Member of ESPGHAN working groups: GI Motility Group, Eosinophilic Esophagitis Group, NAFLD group, Hepatology group, Pancreatic diseases group
  • Author and co-author of more than 200 publications, scientific papers in journals with an impact factor and abstracts presented on national and international congresses and conferences.

•European-Mediterranean Project on Functional Gastrointestinal Diseases in Children ESPGHAN МЕАР study group – Diet and Functional gastrointestinal disorders (FGIDs) in children and adolescents in the Mediterranean countries: an ESPGHAN multicenter study

• МЕАР Study group – Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

• Eosinophilic working group of ESPGHAN – Practical Guideline for Eosinophilic esophagitis

• LQ- Celiac Project

• Implementation of 2009 NASP(;HAN-ESPGHAN guidelines for diagnosis and management of gastroesophageal reflt1x in children

• Amil-Dias Ј, Oliva Ѕ, Papadopoulou А, Thomson М, Gutierrez-Junquera С, Kalach N, Orel R, Auth МК, Nijenhuis-Hendriks D, Strisciuglio С, Bauraind 0, Chong Ѕ, Ortega GD, Fernandez SF, Furman М, Garcia-Puig R, Gottrand F, Homan М, Huysentruyt К, Kostovski А, Otte Ѕ, Rea F, Roma Е, Romano С, Tzivinikos С, Urbonas V, Velde SV, Zangen Т, Zevit N. Diagnosis and
management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Ј Pediatr Gastroenterol Nutr.

2024 Aug;79(2):394-437. doi: 10.1002/jpn3.12188. PMID: 38923067. (IF-3.288)

• Strisciuglio С, Cenni Ѕ, Serra MR, Dolce Р, Kolacek Ѕ, Sila Ѕ, Trivic 1, Bar Lev MR, Shamir R, Kostovski А, Papadopoulou А, Roma Е et al. Diet and Pediatric Functional Gastrointestinal Disorders in Mediterranean Countries. Nutrients. 2022 Jun 2;14(11):2335. doi: 10.3390/nu14112335 (IF-7.185)

• Strisciuglio С, Cenni Ѕ, Serra MR, Dolce Р, Kolacek Ѕ, Sila Ѕ, Trivic 1, Lev MRB, Shamir R, Kostovski А, Papadopoulou А, Roma Е, Katsagoni С, Jojkic-Pavkov D, Salvatore Ѕ, Pensabene L, Scarpato Е, Miele Е, Staiano А. Functional Gastrointestinal Disorders in Mediterranean Countries According to Rome IV Criteria. Ј Pediatr Gastroenterol Nutr. 2022 Mar 1;74(3):361-367 (IF-3.288)

• Gilles Tourlamin, Roger Garcia Puig, Carolina Gutierrez Junquera, Kostovski А et al. Difference in Management ofEosinophilic Esophagitis in Europe: an Assessment of Current practice. Ј Pediatr Gastroenterol Nutr 2020;71(1): 1 278-285 (IF-3.288)

• Scarpato Е, Kolacek Ѕ, Jojkic-Pavkov D, Konjik V, Zivkovic N, Roman Е, Kostovski А, Zdraveska N, Altamimi Е, Papadopoulou А, Karagiozoglou­ Lampoudi Т, Shamir R, Bar Lev MR, Koleilat А, Mneimneh Ѕ, Bruzzese D, Leis R, Staiano А; МЕАР Group. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe. Clin Gastroenterol Hepatol. 2018 Jun;16(6):870-876 (IF-7.896)

• Murch ЅН, Allen К, Chong Ѕ, Dias ЈА, Kostovski А. Papadopoulou А; Eosinophilic Oesophagitis Working Group of ESPGHAN. Poteпtial for improving the1·apy and defining new research targets in eosinopl1ilic oesophagitis based on undeгstanding of immнnopathogenesis. Ј Pediatr Gastгoeпterol Nнtг. 2013 Oct;57(4):529-34. (IF-3.288)

• Kostovski А, Zdraveska N, Tesarova М, Zeman Jiri. First Macedonian child with tyrosinemia type 1 sнccessfнlly treated with nitisinon and report of а novel mнtation in the FAH gene. Srp Arh celok lek. 2017;145 (9-10): 530-533 (IF- 1.142)

• Qнitadamo Р, Urbonas V, Papadopouloн А, Roman Е, Pavkov DJ, Orel R, Dias ЈА, Kostovski А, Miele Е, Villani А, Staiano А. Do pediatricians apply t11e 2009 NASPGHAN-ESPGHAN gt1ideli11es Љr the diagnosis апd maпagemeпt of gastroesoplшgeal retlux afteг being trained? Ј Pediatг Gastroenterol Nt1tг. 2014 Ѕер;59(3):356-9. doi: 10.1097/MPG.0000000000000408. PMID: 24762458. (IF-3.288)

• Quitadamo Р, Papadopoulou А, Wenzl Т, Urbonas V, Dias ЈА, Vandenplas У, Kostovski А, Miele Е, Villani А, Staiano А. European pediatricians’ approach to childI”eп with GER symptoms: ЅШ’vеу of tl1e implemeпtation of’2009 NASPGHAN-ESPGHAN guidelines. Ј Pediatr GastroenteI”ol Nutr. 2014 Apr;58(4):505-9. doi: 10.1097/MPG.Ob013e3182a69912. PMID: 24663035. (IF-3.288)

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